The Transcriptional Regulator AlgR Controls Cyanide Production in Pseudomonas aeruginosa
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چکیده
منابع مشابه
The transcriptional regulator AlgR controls cyanide production in Pseudomonas aeruginosa.
Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic lung infections in cystic fibrosis (CF) patients. One characteristic of P. aeruginosa CF isolates is the overproduction of the exopolysaccharide alginate, controlled by AlgR. Transcriptional profiling analyses comparing mucoid P. aeruginosa strains to their isogenic algR deletion strains showed that the transcription of cya...
متن کاملThe transcriptional regulator AlgR is essential for Pseudomonas aeruginosa pathogenesis.
Chronic Pseudomonas aeruginosa lung infection is the major cause of morbidity and mortality in cystic fibrosis (CF) patients. One P. aeruginosa virulence factor unique to CF isolates is overproduction of alginate, phenotypically termed mucoidy. Mucoidy is the result of increased transcription from the algD gene and is activated by the transcriptional regulator AlgR. Mutations in algR result in ...
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Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic infections in individuals suffering from the genetic disorder cystic fibrosis. In P. aeruginosa, the transcriptional regulator AlgR controls a variety of virulence factors, including alginate production, twitching motility, biofilm formation, quorum sensing, and hydrogen cyanide (HCN) production. In this study, the regulati...
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I nfection and subsequent chronic infection of the cystic fibrosis (CF) lung with organisms such as Pseudomonas aeruginosa probably occurs at an early stage in the life of a child suffering from CF. Clinicians worldwide are eager to isolate the organism as early as possible in an attempt to treat the patient before any permanent damage occurs and hopefully to eliminate the organism completely f...
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AlgR is a key Pseudomonas aeruginosa transcriptional response regulator required for virulence. AlgR activates alginate production and twitching motility but represses the Rhl quorum-sensing (QS) system, including rhamnolipid production. The role of AlgR phosphorylation is enigmatic, since phosphorylated AlgR (AlgR-P) is required for twitching motility through the fimU promoter but is not requi...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2004
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.186.20.6837-6844.2004